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2006•Journal of Henan Medical College for Staff and WorkersRequires access

Mutations in Intron of YYHL Hairless Gene

Wenqiao Zang

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Abstract

Objective To research the gene mutation of Yuyi hairless mice(for short: YYHL).Methods(The partial) hairless gene of YYHL,KM mice,Mus musculus(house mouse) were cloned,sequenced and compared respectively.Results The DNA fragment sequenced of YYHL mice contains 1746 bp,KM mice 1733bp.There were 32 differences in intron,including insertion,deletion and point mutation.Conclusion The hairless character is probably associated with the gene mutation of intron.

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What this paper is about

Objective To research the gene mutation of Yuyi hairless mice(for short: YYHL).Methods(The partial) hairless gene of YYHL,KM mice,Mus musculus(house mouse) were cloned,sequenced and compared respectively.Results The DNA fragment sequenced of YYHL mice contains 1746 bp,KM mice 1733bp.There were 32 differences in intron,including insertion,deletion and point mutation.Conclusion The hairless character is probably associated with the gene mutation of intron.

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Available abstract

Objective To research the gene mutation of Yuyi hairless mice(for short: YYHL).Methods(The partial) hairless gene of YYHL,KM mice,Mus musculus(house mouse) were cloned,sequenced and compared respectively.Results The DNA fragment sequenced of YYHL mice contains 1746 bp,KM mice 1733bp.There were 32 differences in intron,including insertion,deletion and point mutation.Conclusion The hairless character is probably associated with the gene mutation of intron.

Key concepts: Hairless, Intron, Gene, Genetics, Mutation, Biology, Point mutation, Molecular biology

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