ScholarLens Back to search
2009•Unpublished venueRequires access

Expression of tumor suppressor gene PTEN in colorectal cancer tissues

Wenchao Liu

Open publisher page 2 citations

Abstract

Objective:To analyze the expression level of tumor suppressor gene PTEN in human colorectal cancer tissues and the relationship with the biological behavior.Methods:Using immunohistochemistry SP to detect 60 cases of colorectal cancer,60 cases of adjacent normal mucosa for PTEN protein expression.Results:For colorectal cancer the PTEN positive rate was 53.3%(32/60),significantly lower than that in the novmal tissues 100%(60/60).Well-differentiated adenocarcinoma PTEN protein expression with the highest rate of 73.3%(22/30) was significantly higher than the poorly differentiated adenocarcinoma 27.3%(6/22).PFEN protein expression was related with lymph node metastasis(P0.05).Conclusion:PTEN gene is closely related to the development of colorectal cancer may be a sign of biological behavior and reference for colorectal cancer gene therapy.

About this research paper

What this paper is about

Objective:To analyze the expression level of tumor suppressor gene PTEN in human colorectal cancer tissues and the relationship with the biological behavior.Methods:Using immunohistochemistry SP to detect 60 cases of colorectal cancer,60 cases of adjacent normal mucosa for PTEN protein expression.Results:For colorectal cancer the PTEN positive rate was 53.3%(32/60),significantly lower than that in the novmal tissues 100%(60/60).Well-differentiated adenocarcinoma PTEN protein expression with the highest rate of 73.3%(22/30) was significantly higher than the poorly differentiated adenocarcinoma 27.3%(6/22).PFEN protein expression was related with lymph node metastasis(P0.05).Conclusion:PTEN gene is closely related to the development of colorectal cancer may be a sign of biological behavior and reference for colorectal cancer gene therapy.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To analyze the expression level of tumor suppressor gene PTEN in human colorectal cancer tissues and the relationship with the biological behavior.Methods:Using immunohistochemistry SP to detect 60 cases of colorectal cancer,60 cases of adjacent normal mucosa for PTEN protein expression.Results:For colorectal cancer the PTEN positive rate was 53.3%(32/60),significantly lower than that in the novmal tissues 100%(60/60).Well-differentiated adenocarcinoma PTEN protein expression with the highest rate of 73.3%(22/30) was significantly higher than the poorly differentiated adenocarcinoma 27.3%(6/22).PFEN protein expression was related with lymph node metastasis(P0.05).Conclusion:PTEN gene is closely related to the development of colorectal cancer may be a sign of biological behavior and reference for colorectal cancer gene therapy.

Key concepts: PTEN, Colorectal cancer, Immunohistochemistry, Cancer research, Tumor suppressor gene, Suppressor, Metastasis, Cancer

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression of tumor suppressor gene PTEN in colorectal cancer tissues — Research Paper | ScholarLens