Changes of Serum FFA,Hcy and CysC Levels in Diabetic Nephropathies Patients in Different Stages

Objective:To observe the changes of serum free fatty acid(FFA),homocysteine(Hcy),cystatin C(CysC)levels in diabetic nephropathies(DN)patients and the relationship with urinary albumin excretion rate(UAER).Method:178cases of type 2diabetes mellitus(T2DM)were chosed,and they were divided into three groups,namely DM group(n=82),early dibetic nephropathy group(EDN,n=56)and clinical diabetes nephropathy group(CDN,n=40),according to UAER in 24 hours.42healthy individuals were selected as the control group.The levels of serum FFA,Hcy,CysC,urea nitrogen(Urea)and creatinine(Cr)were detected by automatic biochemical analyzers,UAER were detected by automatic special protein analyzer.The relationship of FFA,Hcy,CysC and UAER in EDN,CDN patients were analyzed.Results:Serum FFA,Hcy and CysC levels were higher in EDN,CDN groups than DM and control groups(P0.05),exhibiting CDN group EDN group DM groupcontrol group(P0.05).Correlation analysis showed that blood FFA,Hcy,CysC and UAER had high degree of positive correlation between EDN group and CDN group(P0.01).Conclusion:The development of DN was closely related to the increase of FFA,Hcy and CysC levels.