Protective Effect of Chaenomeles on Experimental Hepatic Injury in Mice

Objective To study the protective effect and mechanism of alcohol extracts of Chaenomeles on experimental hepatic injury in mice.Methods Acute hepatic injury model was induced by injecting CCl4 in mice,and the immunological hepatic injury model was induced in mice by injecting bacillus-calmette guer in(BCG) and lipopolysaccharide(LPS).The activities of ALT and AST in serum,SOD and content of MDA in liver were investigated;and the histological changes of liver were observed.Results Chaenomeles decreased the activities of ALT and AST in mice with acute hepatic injury and immunological hepatic injury,increased the activity of SOD but lowered MDA in liver of mice with immunological hepatic injury,and relieved the histological injury of liver(P0.01,P0.05).Conclusion Chaenomeles has protective effect on acute and immunological hepatic injury in mice,the mechanisms of which may be related to its antioxidant activity.