2011•Heilongjiang Medical JournalRequires access

Bone Marrow Mesenchymal Stem Cell Transplantation for Treatment of Cerebral Infarction in Rats

Yanping Dai

Abstract

Objective To investigate bone marrow mesenchymal stem cells(BMSCs) in SD rats with cerebral infarction the rapeutic effect.Methods BMSCs of SD rats were isolated and cultured.the middle cerebral artery occlusion animal model was established;intravenous injection of BMSCs in PBS control group.rat nerve injury and infarct volume were observed.Results rat nerve function score at the same time points decreased significantly BMSCs transplanted group(P0.05);In BMSCs transplantation group,cerebral infarction area(95±18)mm3,significantly less than the PBS control group(P0.05).Conclusion BMSCs have a therapeutic effect in cerebral infarction rats by intravenous injection.It provided experimental basis for the clinical treatment of cerebral infarction.

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Key concepts: Medicine, Mesenchymal stem cell, Cerebral infarction, Transplantation, Infarction, Bone marrow, Anesthesia, Surgery