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2003•Di-san junyi daxue xuebaoRequires access

Anti-tumor effect of combination of TRAIL and 5-Fu on colon cancer cell line SW480

Li Xiao

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Abstract

Objective To study the anti tumor effect of combination of TRAIL and 5 Fu on colon cancer cell line SW480 Methods The survival fraction of SW480 cells was measured by MTT assay and apoptosis rate was determined by TUNEL method Results A cooperative effect of 30～300 ng/ml TRAIL and 3 0 mmol/L 5 Fu on survival fraction of SW480 cells was found TUNEL revealed that 3 0 mmol/L 5 Fu could enhance TRAIL induced apoptosis of colon cancer cell line SW480 Conclusion The sensitivity of colon cancer cell line SW480 to TRAIL mediated apoptosis is improved by 5 Fu

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Objective To study the anti tumor effect of combination of TRAIL and 5 Fu on colon cancer cell line SW480 Methods The survival fraction of SW480 cells was measured by MTT assay and apoptosis rate was determined by TUNEL method Results A cooperative effect of 30～300 ng/ml TRAIL and 3 0 mmol/L 5 Fu on survival fraction of SW480 cells was found TUNEL revealed that 3 0 mmol/L 5 Fu could enhance TRAIL induced apoptosis of colon cancer cell line SW480 Conclusion The sensitivity of colon cancer cell line SW480 to TRAIL mediated apoptosis is improved by 5 Fu

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Available abstract

Objective To study the anti tumor effect of combination of TRAIL and 5 Fu on colon cancer cell line SW480 Methods The survival fraction of SW480 cells was measured by MTT assay and apoptosis rate was determined by TUNEL method Results A cooperative effect of 30～300 ng/ml TRAIL and 3 0 mmol/L 5 Fu on survival fraction of SW480 cells was found TUNEL revealed that 3 0 mmol/L 5 Fu could enhance TRAIL induced apoptosis of colon cancer cell line SW480 Conclusion The sensitivity of colon cancer cell line SW480 to TRAIL mediated apoptosis is improved by 5 Fu

Key concepts: Apoptosis, TUNEL assay, Colorectal cancer, Cell culture, MTT assay, Cancer, Cancer research, Medicine

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Anti-tumor effect of combination of TRAIL and 5-Fu on colon cancer cell line SW480 — Research Paper | ScholarLens