Changes of pathology and cardiac function in murine myocardial infarction model established by coronary artery ligation

Objective: To study the changes of pathology and cardiac function in murine myocardial infarction model by using coronary artery ligation.Methods: The left anterior descending coronary artery was ligated.The changes of echocardiography and myocardial pathology were observed.Results: After coronary artery ligation,the left ventricular end-diastolic and end-systolic diameters increased,and the fractional shortening(FS) and ejection fraction(EF) decreased.In the early stage of myocardial ischemia,the inflammatory cells infiltrated,and the membranes of cardiac myocytes were incomplete.In the late stage,the myocardial fiber was fractured,and cardiac myocytes were necrotic.Conclusion: Murine myocardial infarction model could be established successfully by coronary artery ligation.