Clinical application of fetal chromosomal Karyotypes during the second and third trimester of gestation

Objective:Through analyzing the fetal chromosomal karyotypes in amniotic fluid and cord blood to investigate the relationship between abnormal karyotypes and indications of prenatal diagnosis.Methods:Amniocentesis and cordocentesis were performed in 119 pregnant women and fetal chromosomal karyotypes were examined in amniotic fluid and cord blood.Results:8 abnormal chromosomal karyotypes were detected and the abnormal rate was 6.72%(8/119.Trisomy was the leading abnormality which was 4 out of 8 (50%). Chromosomal translocation was in the second place which was 2 out of 8(25%.Conclusion:Among pregnant women in the second and third trimester with different indications of prenatal diagnosis, the rate of fetal chromosomal abnormality was 6.72%. The most common abnormality was trisomy. Ultrasound examination as prenatal routine examination can increase the antenatal detective rate of fetal chromosomal abnormality.