A Study of Paroxetine Combining with Risperidone in the Treatment of Obsessive-compulsive Disorder

Objective To explore the efficacy and side effect of paroxetive combining with low dose risperidone in the treatment of obsessive-compulsive disorder. Methods 74 patients who met the criteria of CCMD-3 for obsessive-compulsive disorder were assigned to study group and control group, study group were given paroxetine combining risperidone, control group given paroxetine only. The effect was assessed with Y-BOCS、HAMD、HAMA at the end of 2nd、4th、6th and 8th, and noted the side effect. Results After treatment, scores of Y-BOCS、HAMD and HAMA of both groups were significantly lower than pre-treatment(P0.05 or 0.01). There were significant differences in the scores of Y-BOCS and HAMA between two groups at the end of 6th and 8th (P0.05). The effective rate of study group (81.08%) were higher than control group (59.46%, P0.05). There were no significantly difference in side effect between two groups (P0.05). Conclusion Paroxetine combining with low dose risperidone has better effect in the treatment of obsessive-compulsive disorder than paroxetine only, it has fewer side effects.