Effects and Prognosis of Transcatheter Arterial Chemoembolization for Patients with Primary Hepatocellular Carcinoma Combining with Different type of Posthepatitic Cirrhosis

Objective: To evaluate the liver function,Coagulation Function and the effects of transcatheter aneria1 chemoembolization(TACE) on patients with primary hepatocellular carcinoma(PHC) combining with different type of posthepatitic cirrhosis.Methods: 131 patients diagnosed as primary hepatocellular carcinoma(PHC) combining with different type of posthepatitic cirrhosis by TACE in our department from August 2007 to August 2009 were included in this study.The patients were divided into two groups: these cases with(PHC) combining with liver cirrhosis with chronic hepatitis B in group1,liver cirrhosis with chronic hepatitis C in group 2.Follow-up 1 year for the clinical and laboratory data(include ALT,AST,GGT,ALP,PT,PLT) and the overall survival rates.Chi-square statistics,Kaplan-Meier and Log-rank method were used to determine factors and survival rates by SPSS17.0.Results: The statistics results by 1 year follow-up shows that there was no significant difference in AST,ALT,ALP,GGT,PT,PLT six months and one year after TACE(P0.05);the distant metastasis rate of six months and 1 year has no significant difference in two groups(P0.05),0.841).For group 1,six months and 1 year overall survival rates were 70.1%,48.1%,respectively,for group 2,they were 68.5%,58.9%,respectively.There was not significant difference in six months and 1 year survival rates between 2 groups(X2=0.039,P=0.884;X2=0.183,P=0.669).Conclusions: The efficacy of liver function,Coagulation Function and prognosis of TACE for PHC combining with liver cirrhosis with chronic hepatitis B or C were similar.