Clinical study of antiviral treatment combined with transcatheter arterial chemoemholization(TACE) in patients with hepatitis B cirrhosis complicated hepatocellular carcinoma

Objective To investigate the effects of antiviral treatment combined with transcatheter arterial chemoemholization(TACE)in patients with hepatitis B cirrhosis complicated hepatocellular carcinoma(HCC).Methods Retrospectively analyzed the effects of antiviral treatment combined with TACE in 78 cases with Hepatitis B cirrhosis complicated HCC,and compared with 81 patients that separately used TACE at the same time.One or two years′ survival rate,Child-Pugh score and HBV DNA were measured.There were no significant differences between two groups in basic clinical materials(P0.05)(include sex,age,tumor size,laboratory examination and Child-Pugh score).Results After one or two years′ treatment,the conversion rates of HBV DNA of treatment group were significantly higher than those of the control group(P0.0001),Child-Pugh scores of treatment group were significantly lower than those of the control group(P0.001),the differences were significantly.The one or two years′ survival rates of treatment group were 83.33% and 66.67%,while control group were 59.2% and 36.67%(P0.001),the differences were significantly.Conclusion Nucleoside analogues combined with TACE,can reduce the level of HBV DNA,protect liver functions and increase survival rates considerably in patients with hepatitis B cirrhosis complicated HCC.