2008•Chinese Journal of Birth Health & HeredityRequires access
Significant of NS gene on curcumin inhibitory cell proliferation in gastric carcinoma SGC-7901cells.
Wei Sun
Open publisher page 0 citations
Abstract
Objective:To investigate the effect of NS gene on gastric-carcinoma cells proliferation and apoptosis induced by curcumin.Methods:SGC-7901cells were treated with various of curcumin,we detected the rate of cell proliferation inhibition by MTT assay;detected the levels of NS gene expression in all groups by RT-PCR;detected cell cycle and cell apoptosis by flow cytometry.Results:Curcumin could effectively inhibit the SGC-7901cells proliferation in dose-dependent and time-dependent manner,reduce the level of NS gene expression,the percent of G0/ G1 phase cell increase with the decrease of S phase and sub-peak of apoptosis appear.Conclusion:Curcumin could substantially inhibit SGC-7901 cells proliferation,inducing apoptosis probably through down regulating NS gene expression.