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Study on HPMC Matrix Tablets of Metformin Hydrochloride

XU Qun

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Abstract

The HPMC matrix tablets of Metformin hydrochloride(MH) was compressed by using wet method. The effect of the amount, viscosity of hydroxypropylmethylcellulose and species of bonding agent such as ethyl cellulose, alcohol, EudragitⅢ on the MH release rate from matrix tablets was investigated. The experimental design using orthogonal table has shown that the amount and species of bonding agent were affected in the MH release rate from matrix tablets and the viscosity of HPMC was not significant.

About this research paper

What this paper is about

The HPMC matrix tablets of Metformin hydrochloride(MH) was compressed by using wet method. The effect of the amount, viscosity of hydroxypropylmethylcellulose and species of bonding agent such as ethyl cellulose, alcohol, EudragitⅢ on the MH release rate from matrix tablets was investigated. The experimental design using orthogonal table has shown that the amount and species of bonding agent were affected in the MH release rate from matrix tablets and the viscosity of HPMC was not significant.

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Available abstract

The HPMC matrix tablets of Metformin hydrochloride(MH) was compressed by using wet method. The effect of the amount, viscosity of hydroxypropylmethylcellulose and species of bonding agent such as ethyl cellulose, alcohol, EudragitⅢ on the MH release rate from matrix tablets was investigated. The experimental design using orthogonal table has shown that the amount and species of bonding agent were affected in the MH release rate from matrix tablets and the viscosity of HPMC was not significant.

Key concepts: Metformin Hydrochloride, Ethyl cellulose, Matrix (chemical analysis), Viscosity, Chemistry, Chromatography, Hydrochloride, Polyvinyl alcohol

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