Research Progress of the Relationship between Serum Uric Acid Level and Ischemic Stroke

A wealth of prospective and epidemiological evidence have identified an association between elevated serum uric acid level and morbidity,mortality and neurologic impairment related to stroke,while some have reported that elevated serum uric acid may be an independent risk factor of stroke.In addition,uric acid as the most important endogenous antioxidant in human,it may play a role in the protection against oxidative stress in acute ischemic stroke.Elevated serum uric acid may accelerate the oxidative stress in the lower total antioxidant activity of plasma.Recently,the animal experiment evidence have supported that the dual administration of exogenous UA and rt-PA may increase the clinical effect of rt-PA thrombolytic therapy.So far,the relationship between elevated serum uric acid and acute ischemic stroke is still controversial.