ROLE OF INCREASED SERUM URIC ACID IN STROKE

The role of hyperuricemia as a risk factor for acute stroke is debatable as it is not clear whether Serum Uric Acid (SUA) promotes or protects against the cerebrovascular disease.In this study, the serum uric acid level and other risk factors like lipid profile, S. Adenosine Deaminase was estimated in patients with acute stroke and their relationship with ischemic stroke, and the association of factors like age, sex, obesity and smoking in the development of ischemic stroke.METHODS: A prospective, randomized study conducted on 100 cases of ischemic stroke presenting to Department of Medicine, GMC, Amritsar.Risk factors for stroke were noted such as hypertension, diabetes mellitus, metabolic syndrome, smoking, and obesity.Serum uric acid levels were measured in cases and controls.In addition the measurement of other risk factors likes lipid profile, Fasting blood sugar and S. Adenosine deaminase was done.The collected data were analyzed using Student's t-test.RESULTS: Out of 100 patients, 69 were males and 31 were females.The hyperuricemia and ischemic stroke was more in males than females (46 vs. 23).Hyperuricemia and ischemic stroke was associated with higher FBS (mg/dl) 122.33±18.46 and 129.37±15.40,HbA1c (mg/dl) 6.87±2.1 and 6.82±6.21,S. Triglyceride (mg/dl) 162.34±14.08 and 154.34±10.12,S. Total Cholesterol (mg/dl) 169±12.10 and 160.09±14.10,S.HDL-C (mg/dl) 42.11±10.17and 45.16±11.40,S.LDL-C (mg/dl) 119.85±14.07 and 110.42±12.67,S.ADA (U/L) 45.62±7.90 and 49.47±9.57at admission and at discharge respectively compared to the control.CONCLUSIONS: Hyperuricemia and ischemic stroke was significantly higher in patients with hypertension, Diabetes mellitus, metabolic syndrome, chronic smokers and BMI > 25 kg/m2.So control of these factors should be done to prevent future onset of ischemic stroke.