Clinical Observation of Thymosin Alpha-1 Preventing Frequent Relapse Nephrotic Syndrome in Children

Objective: To explore the effect of thymosin alpha-1 on preventing primary nephrotic syndrome.Methods: Sixty frequently relapsing patients were randomly divided into intervention group(n = 30) and control group(n = 30).Both were given the comprehensive treatment (steroid).The patients of intervention group were also given thymosin alpha-1 (1.6 mg),injected hypodermically,5 days a term,another term was repeated if necessary.The levels of CD3+,CD4+,CD8+ and CD4+/CD8+ were tested before and after the intervention.Results: The levels of CD3+,CD4+ and CD4+/CD8+ increased and CD8+ decreased more significantly after the treatment(P 0.05).The levels of CD4+ and CD4+/CD8+ increased more significantly,but CD8+ decreased more significantly in the intervention group than those in control group (P 0.05).The relapse rate was significantly lower in the intervention group than that of the control group.Conclusion: Thymosin alpha-1 can regulate T cell effectively,increase cell immunity,enhance the immunity to infection and prevent frequent relapse of primary nephrotic syndrome.