2008•Zhongguo xin yao zazhiRequires access

Synthesis of ketoprofen

Li Xiang

Abstract

Objective: To investigate the synthesis of ketoprofen. Methods: Started from 3-cya-nomethylbenzoic acid,the ketoprofen was synthesized via 3-step reactions,i.e.Friedel-Crafts,α-monomethylation and hydrolysis.Results: The total yield of ketoprofen was 73.8% and the purity was 99.8%.Conclusion: This new synthetic procedure with lower cost and higher yield is suitable for industrial production.

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Available abstract

Key concepts: Ketoprofen, Yield (engineering), Chemistry, Hydrolysis, Organic chemistry, Total synthesis, Chromatography, Materials science