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[The influence of COX-2 depressant in angiogenesis of oral squamous cell carcinoma].

Xiao-ju Sun, Hong Xie, Xukai Wang, Hui Zhang, Cong-Xiao Song, Yujie Zhang

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Abstract

PURPOSE: To investigate the COX-2 depressant on cell apoptosis and angiogenesis of oral squamous cell carcinoma. METHODS: RT-PCR and Western blotting were used to detect the effect of NS-398, the COX-2 inhibitor on mRNA and protein expression of VEGF and Survivin in oral squamous carcinoma cell line Tca8113. SPSS11.5 software package was used for statistical analysis. RESULTS: NS-398 could down-regulate the expression of VEGF and Survivin in Tca8113 in a time-dependent manner. CONCLUSIONS: NS-398 could down-regulate the expression of VEGF and survivin in Tca8113 and plays an important role in cell apoptosis and angiogenesis of oral squamous cell carcinoma.

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What this paper is about

PURPOSE: To investigate the COX-2 depressant on cell apoptosis and angiogenesis of oral squamous cell carcinoma. METHODS: RT-PCR and Western blotting were used to detect the effect of NS-398, the COX-2 inhibitor on mRNA and protein expression of VEGF and Survivin in oral squamous carcinoma cell line Tca8113. SPSS11.5 software package was used for statistical analysis. RESULTS: NS-398 could down-regulate the expression of VEGF and Survivin in Tca8113 in a time-dependent manner. CONCLUSIONS: NS-398 could down-regulate the expression of VEGF and survivin in Tca8113 and plays an important role in cell apoptosis and angiogenesis of oral squamous cell carcinoma.

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Available abstract

PURPOSE: To investigate the COX-2 depressant on cell apoptosis and angiogenesis of oral squamous cell carcinoma. METHODS: RT-PCR and Western blotting were used to detect the effect of NS-398, the COX-2 inhibitor on mRNA and protein expression of VEGF and Survivin in oral squamous carcinoma cell line Tca8113. SPSS11.5 software package was used for statistical analysis. RESULTS: NS-398 could down-regulate the expression of VEGF and Survivin in Tca8113 in a time-dependent manner. CONCLUSIONS: NS-398 could down-regulate the expression of VEGF and survivin in Tca8113 and plays an important role in cell apoptosis and angiogenesis of oral squamous cell carcinoma.

Key concepts: Survivin, Angiogenesis, Cancer research, Apoptosis, Basal cell, Carcinoma, Cell growth, Squamous carcinoma

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[The influence of COX-2 depressant in angiogenesis of oral squamous cell carcinoma]. — Research Paper | ScholarLens