Expression of GLUT-1 and VEGF in endometrial adenocarcinoma tissues

OBJECTIVE: To investigate the expression of glucose transpoter protein-1(GLUT-1) and vascular endothelial growth factor(VEGF) in endometrial simple hyperplasia,complex hyperplasia,atypical hyperplasia and endometrial adenocarcinoma.METHODS: The immunohistochemical(PV9000 two-step) method was applied to detect the expression of GLUT-1 and VEGF in the endometrial simple hyperplasia(15 cases),complex hyperplasia(12 cases),atypical hyperplasia(18 cases),and endometrial adeno-carcinoma(36 cases).RESULTS: The difference of expression of GLUT-1 and VEGF in endometrial adenocarcinoma were 83.3% and 75.0%,which were significantly different from those in endometrial simple hyperplasia,complex hyperplasia and atypical hyperplasia tissue were statistically significant(P0.05).There were positive correlation anmong GLUT-1 and VEGF(r=0.65,P0.01).CONCLUSIONS: GLUT-1 and VEGF can play important roles in the development of endometrial carcinoma.The expression of GLUT-1 is positively associated with VEGF.They play important roles in the carcinogenesis of endometrial carcinoma,and has certain value in clinical application.