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[A study on the effects of CD3AK cells on the improvement of cellular immune function in burned patients].

Jinan Zhan, Li G, G Li

Abstract

OBJECTIVE: To explore new ways of correcting postburn immune suppression in severely burned patients. METHODS: CD3AK cells were cultured in serum-free medium and were employed to treat patients with major burns. Similar patients treated by routine treatment were set to be control group. The changes of cellular immunological indices were dynamically observed in the patients of two groups at different time points. RESULTS: Compared to those in control group, the ratio of CD4+ cell of T cell subgroup increased in patients treated by CD3AK, in concomitant with the decrease of the ratio of CD8+ cells and the increase of the ratio of CD4/CD8. Serum soluble IL-2R level decreased. T lymphocyte transforming activity increased and NK cell activity increased. CONCLUSION: CD3AK cells cultured in serum-free medium could improve and restore the decreased cellular immune function in burn patients.

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Key concepts: Immune system, CD8, Immunology, Concomitant, Cellular immunity, Cell, Lymphocyte, Medicine