Expression and significance of VEGF-D in thyroid carcinoma.

Objective:The expression of VEGF-D was investigated in thyroid cancer and its clinical significance was studied.Method:Expression of VEGF-D was examined in specimens of 16 normal thyroid tissue and 56 thyroid cancer tissue by the technique of the immunohistochemistry.Result:i.The positive expression of VEGF-D was located in cytoplasm of tumor cells and cell-membrance,The positive rates of VEGF-D in neighboring normal thyroid tissues and thyroid cancer were 18.7%(3/16),71.4%(41/56) respectively,they was significant difference(p0.05).ii.The expression of VEGF-D in thyroid cancer 83.8%(26/31)with lymph node metastasis was higher than that in thyroid cancer without lymph metastasis 60%(15/25),which was significant difference.iii.The expression of VEGF-D in papillary thyroid cancer 85.1% with lymph node metastasis was higher than that in thyroid cancer 50% without lymph metastasis,they was significant difference.Conclusion:The expression of VEGF-D in neighboring normal thyroid tissues is significantly lower than that in thyroid cancer tissue.(p0.05) The expression of VEGF-D increased in papillary thyroid cancer,especially while metastasis occurred,which could indicate the relation between the expression of VEGF-D and lymph node metastasis.