Evaluation on laboratory indexes in treating chronic hepatitis B.

Objective To observe the therapy effect of lamivudine on chronic hepatitis B patients by nuclear quantitative method and other liver function indexes.Methods To select 456 cases of chronic hepatitis B paticnts.Among them,356 cases of the treatment group were treated by lamivudine 100mg once daily,100 cases of the control group,not treated by lamivudine.All of them were examined by HBV-DNA quantities method,HBV-M,liver function.Results After one year treament,181 cases of HBV-DNA turned to negative(103cps/mL)(50.8%),4 cases of the control group turned to negative(4%)(P0.01).Abnormal ALT and AST in 703 of 786 cases of the treatment group turned to normal(89.4%)(P0.01),HBeAg of 84 cases in the treatment group turned to anti-HBe(19.2%),HBeAg in 62 cases turned to negative(14.2%),5 cases HBeAg turned to anti-HBe and negative.Conclusion Lamivudine could restrain the copy of HBV effectively in the treatment of drug,reduce ALT and AST,accelerate HBeAg turn to anti-HBe.