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Predicting Response to Hepatitis B Virus Therapy

Atif Zaman

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Abstract

Hepatitis B virus surface antigen (HBsAg) loss and, ultimately, seroconversion to hepatitis B surface antibodies might be the only indicator of true clearance of hepatitis B virus (HBV) in chronically infected patients. Pegylated interferon (PEG-IFN) alfa-2a–based therapy can induce HBsAg seroconversion in some hepatitis B e antigen (HBeAg)-negative patients. Now two groups of researchers have examined the usefulness of HBsAg levels during and after HBV therapy as predictors of treatment response to PEG-IFN. Moucari and colleagues prospectively evaluated 48 patients with HBeAg-negative …

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What this paper is about

Hepatitis B virus surface antigen (HBsAg) loss and, ultimately, seroconversion to hepatitis B surface antibodies might be the only indicator of true clearance of hepatitis B virus (HBV) in chronically infected patients. Pegylated interferon (PEG-IFN) alfa-2a–based therapy can induce HBsAg seroconversion in some hepatitis B e antigen (HBeAg)-negative patients. Now two groups of researchers have examined the usefulness of HBsAg levels during and after HBV therapy as predictors of treatment response to PEG-IFN. Moucari and colleagues prospectively evaluated 48 patients with HBeAg-negative …

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Available abstract

Hepatitis B virus surface antigen (HBsAg) loss and, ultimately, seroconversion to hepatitis B surface antibodies might be the only indicator of true clearance of hepatitis B virus (HBV) in chronically infected patients. Pegylated interferon (PEG-IFN) alfa-2a–based therapy can induce HBsAg seroconversion in some hepatitis B e antigen (HBeAg)-negative patients. Now two groups of researchers have examined the usefulness of HBsAg levels during and after HBV therapy as predictors of treatment response to PEG-IFN. Moucari and colleagues prospectively evaluated 48 patients with HBeAg-negative …

Key concepts: HBsAg, Medicine, HBeAg, Seroconversion, Hepatitis B virus, Virology, Pegylated interferon, Immunology

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