2006Bulletin of Pharmaceutical Sciences AssiutOpen access

PHENOLICS OF CYPERUS ALOPECUROIDES ROTTB. INFLORESCENCES AND THEIR BIOLOGICAL ACTIVITIES

H. Sayed, Marwa El-Badry Mohamed, Salwa F. Farag, Gamal A. Mohamed, Rainer Ebel, O.R. Omobuwajo, Peter Proksch

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Abstract

Sixteen phenolic compounds, scopoletin (1), isoliquiritigenin 4-methyl ether (2), luteolin 5,3-dimethyl ether (3), luteolin 7,3-dimethyl ether (4), aureusidin 4-methyl ether (5), apigenin (6),luteolin (7), trans-ferulic acid (8), luteolin 4-O- -D-glucopyranoside(9), luteolin 7-O- -D-glucopyranoside (10), quercetin3-O- -D-glucopyranoside (11), apigenin 7-O-neohesperidoside(12), kaempferol 3-O-rutinoside (13), quercetin 3-O-rutinoside(14), kaempferol 3-O-[2-O-D-xylopyranosyl-6-O--L-rhamnopyranosyl]- -D-glucopyranoside (15) and kaempferol 3-O-[2-OD-glucopyranosyl-6-O--L-rhamnopyranosyl]- -D-glucopyranoside(16) were isolated from the methanolic extract of theinflorescences of Cyperus alopecuroides Rottb. for the first time.Their structures have been established on the basis of physical,chemical and spectroscopic methods in addition to comparisonwith literature data and/or authentic samples. The antioxidant andcytotoxic activities in addition to -amylase inhibitory activity ofthe isolated compounds have been studied.

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Sixteen phenolic compounds, scopoletin (1), isoliquiritigenin 4-methyl ether (2), luteolin 5,3-dimethyl ether (3), luteolin 7,3-dimethyl ether (4), aureusidin 4-methyl ether (5), apigenin (6),luteolin (7), trans-ferulic acid (8), luteolin 4-O- -D-glucopyranoside(9), luteolin 7-O- -D-glucopyranoside (10), quercetin3-O- -D-glucopyranoside (11), apigenin 7-O-neohesperidoside(12), kaempferol 3-O-rutinoside (13), quercetin 3-O-rutinoside(14), kaempferol 3-O-[2-O-D-xylopyranosyl-6-O--L-rhamnopyranosyl]- -D-glucopyranoside (15) and kaempferol 3-O-[2-OD-glucopyranosyl-6-O--L-rhamnopyranosyl]- -D-glucopyranoside(16) were isolated from the methanolic extract of theinflorescences of Cyperus alopecuroides Rottb. for the first time.Their structures have been established on the basis of physical,chemical and spectroscopic methods in addition to comparisonwith literature data and/or authentic samples. The antioxidant andcytotoxic activities in addition to -amylase inhibitory activity ofthe isolated compounds have been studied.

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Available abstract

Sixteen phenolic compounds, scopoletin (1), isoliquiritigenin 4-methyl ether (2), luteolin 5,3-dimethyl ether (3), luteolin 7,3-dimethyl ether (4), aureusidin 4-methyl ether (5), apigenin (6),luteolin (7), trans-ferulic acid (8), luteolin 4-O- -D-glucopyranoside(9), luteolin 7-O- -D-glucopyranoside (10), quercetin3-O- -D-glucopyranoside (11), apigenin 7-O-neohesperidoside(12), kaempferol 3-O-rutinoside (13), quercetin 3-O-rutinoside(14), kaempferol 3-O-[2-O-D-xylopyranosyl-6-O--L-rhamnopyranosyl]- -D-glucopyranoside (15) and kaempferol 3-O-[2-OD-glucopyranosyl-6-O--L-rhamnopyranosyl]- -D-glucopyranoside(16) were isolated from the methanolic extract of theinflorescences of Cyperus alopecuroides Rottb. for the first time.Their structures have been established on the basis of physical,chemical and spectroscopic methods in addition to comparisonwith literature data and/or authentic samples. The antioxidant andcytotoxic activities in addition to -amylase inhibitory activity ofthe isolated compounds have been studied.

Key concepts: Luteolin, Chemistry, Apigenin, Kaempferol, Scopoletin, Ether, Quercetin, Organic chemistry

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