1987•The Journal of AntibioticsOpen access

Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor.

Sheri P. Cole, Brian A.M. Rudd, David A. Hopwood, Chin-Jer Chang, Heinz G. Floss

Abstract

From two types of class V act mutants of Streptomyces coelicolor two monomeric precursors of actinorhodin have been isolated and their structures determined. One is the known antibiotic kalafungin and the other a new compound. Their relationship to actinorhodin biosynthesis is discussed.

Open-access reader

About this research paper

What this paper is about

Why it matters

OpenAlex reports 81 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Actinorhodin, Streptomyces coelicolor, Mutant, Antibiotics, Streptomycetaceae, Biosynthesis, Microbiology, Streptomyces