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1987•The journal of the Japanese Practical Surgeon SocietyOpen access

EXCRETION OF CEFTIZOXIME IN BILE AND GALLBLADDER TISSUE

Kiyoshi YOSHIKAWA, Motonobu Nishimura, Shigeru Imabun, Norio HAN, Atsushi Ito

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Abstract

We measured the concentrations of the antibiotic Ceftizoxime (CZX) in the bile and gallbladder tissue and examined the prevalence of bacteria in the bile of 61 patients undergoing elective cholecystectomy. The drug (2g) was given IV preoperatively. The results were as follows. 1) CZX was well concentrated in the bile sampled from the gallbladder and the bile duct. CZX concentration of bile in the radiologically nonfunctioning gallbladder showed considerable variation and was lower compared with the functioning gallbladder. 2) The values for CZX concentration of the tissue were high, and there was no correlation between the tissue concentration and degree of inflammation. 3) Bacteria were isolated at operation from the bile in seven out of 38 patients (18.4%). There was a higher incidence of bile bacteria in the radiologically nonfunctioning gallbladder compared with the functioning gallbladder (30.8% and 12.8%, respectively).

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We measured the concentrations of the antibiotic Ceftizoxime (CZX) in the bile and gallbladder tissue and examined the prevalence of bacteria in the bile of 61 patients undergoing elective cholecystectomy. The drug (2g) was given IV preoperatively. The results were as follows. 1) CZX was well concentrated in the bile sampled from the gallbladder and the bile duct. CZX concentration of bile in the radiologically nonfunctioning gallbladder showed considerable variation and was lower compared with the functioning gallbladder. 2) The values for CZX concentration of the tissue were high, and there was no correlation between the tissue concentration and degree of inflammation. 3) Bacteria were isolated at operation from the bile in seven out of 38 patients (18.4%). There was a higher incidence of bile bacteria in the radiologically nonfunctioning gallbladder compared with the functioning gallbladder (30.8% and 12.8%, respectively).

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Available abstract

We measured the concentrations of the antibiotic Ceftizoxime (CZX) in the bile and gallbladder tissue and examined the prevalence of bacteria in the bile of 61 patients undergoing elective cholecystectomy. The drug (2g) was given IV preoperatively. The results were as follows. 1) CZX was well concentrated in the bile sampled from the gallbladder and the bile duct. CZX concentration of bile in the radiologically nonfunctioning gallbladder showed considerable variation and was lower compared with the functioning gallbladder. 2) The values for CZX concentration of the tissue were high, and there was no correlation between the tissue concentration and degree of inflammation. 3) Bacteria were isolated at operation from the bile in seven out of 38 patients (18.4%). There was a higher incidence of bile bacteria in the radiologically nonfunctioning gallbladder compared with the functioning gallbladder (30.8% and 12.8%, respectively).

Key concepts: Gallbladder, Ceftizoxime, Gastroenterology, Cholecystectomy, Internal medicine, Bile duct, Medicine, Antibiotics

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