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Chronotropic and Inotropic Effects of Prostaglandins E1, A1, and F2 on Isolated Mammalian Cardiac Tissue

Jong-Chyi Su, Charles B. Higgins, W. F. Friedman

Open publisher page 10 citations

Abstract

This study indicates that the chronotropic and inotropic effects of PG on isolated cardiac muscle are species dependent. While a direct chronotropic effect was observed on the atrial tissue of the cat, the PG appear to be devoid of direct chronotropic effects on canine cardiac tissue and of direct inotropic effects in both feline and canine cardiac tissue.

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What this paper is about

This study indicates that the chronotropic and inotropic effects of PG on isolated cardiac muscle are species dependent. While a direct chronotropic effect was observed on the atrial tissue of the cat, the PG appear to be devoid of direct chronotropic effects on canine cardiac tissue and of direct inotropic effects in both feline and canine cardiac tissue.

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OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

This study indicates that the chronotropic and inotropic effects of PG on isolated cardiac muscle are species dependent. While a direct chronotropic effect was observed on the atrial tissue of the cat, the PG appear to be devoid of direct chronotropic effects on canine cardiac tissue and of direct inotropic effects in both feline and canine cardiac tissue.

Key concepts: Chronotropic, Inotrope, Internal medicine, Cardiac muscle, Contractility, Endocrinology, Cardiology, Medicine

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