A case of giant cell reparative granuloma of the bilateral mandible

Giant cellular lesions are characterized by the presence of multinuclear cells, and those known to develop in the intramaxillary regions include giant cytoma, giant cellular granuloma, brown tumor, Cherubism, etc.Modifiable giant cellular granuloma that were advanced by Jaffe (1953) have been treated as giant cellular epulis or giant cellular granuloma, which develops in a perimaxillary region, and central giant cellular granuloma which develops in an intramaxillary region.As we experienced suspected the central giant cellular modifiable granuloma in a 6.7-year old boy that developed in the bilateral mandibular molar regions, we report our pathological findings in addition to some discussions on the published literatures.The diagnosis in this patient was established as central giant cellular modifiable granuloma, although the symptoms initially suspected as Cherubism were neither clinically nor genetically confirmed.