Growth and S35 Uptake of Cotton Granulomas in Rats

1) Cotton pellets implanted subcutaneously in rats induced growth of foreign body granulomas that did not completely penetrate the pellet or reach maximal weight until 50 days. As granulomas aged, shifts in connective tissue elements coincided with increases in uptake of labeled sulfate. 2) Cortisol treatment decreased S35 incorporation into both granuloma and normal connective tissue. Phenylbutazone reduced labeled sulfate uptake by granulomas, but not normal connective tissue, while 17α-ethyl-19-nortestosterone had no effect on either.