The Effects of Carbon Tetrachloride Administration on Liver and Renal Function

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Carbon tetrachloride (CCl 4 ) that induces liver damage is widely used in hepatoprotector experiments. Carbon tetrachloride at a single dose 0,1; 1,0; and 10 ml/kg body weight was administrated intraperitoneally in male rats to investigate liver and renal damage. Liver damage was monitored by increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin, and serum total protein. Increased serum creatinine is an indicator of renal problem. Futhermore, liver and renal tissues were subjected to histopathological studies. Compared with control, injection of 0,1 and 1,0 ml CCl 4 /kg body weight increased ALT and decreased AST, and at dose 10 ml/kg body weight both ALT and AST decreased to a greater extent (p<0.05). Alkaline phosphatase, total bilirubin, and total protein were not different in all treatments (p>0.05). Carbon tetrachloride at dose 0,1 and 1,0 ml/kg body weight increased creatinine. However, injection of 10 ml CCl 4 /kg body weight decreased creatinine (p<0.05). Histopathological studies confirmed the presence of steatosis in hepatic cells at single dose of 1,0 and 10 ml CCl 4 /kg body weight, with no significant effect in glomerulus. Administration of single dose of CCl 4 can induce liver and renal damage that dependent on CCl 4 received.