2013•Okayama Igakkai Zasshi (Journal of Okayama Medical Association)Open access
Mesalazine suppositories and their clinical application
Keiko Funagakure, Syuzi Horita, Terutaka Hamaoka, Takeshi Tasaka, Hiroshi Tatibana, Takako Murakami, Tatuya Toyokawa, Eiji Sato, Jun Tomoda
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Abstract
Ulcerative proctitis (UP) is a prevalent condition associated with increased morbidity, and topical mesalazine (5-aminosalicylic acid [5-ASA]) is known to inhibit the inflammatory processes in UP. We successfully devised mesalazine suppositories, in which 250mg mesalazine was equally distributed and remained stable for at least 2 weeks. We evaluated the effect of using mesalazine suppositories twice a day (BID) on two UP patients. The results demonstrated that mesalazine suppositories were efficacious, well tolerated and safe for the long-term maintenance of UP remission.
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