Antibody Response to Asian Influenza Vaccination in Man.

The route of administration, either intradermal, subcutaneous, or intramuscular, did not significantly affect the antibody response following Asian influenza vaccination. Antibody titers produced were proportional to the total amount of vaccine inoculated whether given as a single dose or divided into 2 injections separated by an interval of 3 weeks. Hemagglutination-inhibition antibody titers in post-vaccinal sera were greater when determined with the TC and EFME lines of Asian virus than with early or later passages of the straight E line. Neutralization titers with the TC line in monkey cultures were considerably greater than those determined with the E lines in the allantoic sac. The geometric mean hemagglutination-inhibition antibody titer of a large group of postinfluenzal sera was used as the baseline for evaluation of antibody response to vaccine by using the same virus line and method of in-activation of non-specific inhibitor in sera in both cases.