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1983•Japanese Journal of Hospital PharmacyOpen access

Method of Dissolution Test for a Practically Insoluble Drug, Glibenclamide

Nobuo Inotsume, REIKO IWAOKU, Masahiro Nakano

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Abstract

A dissolution test for practically insoluble drugs was developed and applied to 4 preparations of glibenclamide. The results showed that with this method it has become possible to evaluate the difference of dissolution rate of the preparations with good reproducibility for dissolution profile. Two preparations of glibenclamide made by 1 manufacturer indicated that their dissolution rates were much lower than those of 2 preparations made by the other.

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A dissolution test for practically insoluble drugs was developed and applied to 4 preparations of glibenclamide. The results showed that with this method it has become possible to evaluate the difference of dissolution rate of the preparations with good reproducibility for dissolution profile. Two preparations of glibenclamide made by 1 manufacturer indicated that their dissolution rates were much lower than those of 2 preparations made by the other.

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Available abstract

A dissolution test for practically insoluble drugs was developed and applied to 4 preparations of glibenclamide. The results showed that with this method it has become possible to evaluate the difference of dissolution rate of the preparations with good reproducibility for dissolution profile. Two preparations of glibenclamide made by 1 manufacturer indicated that their dissolution rates were much lower than those of 2 preparations made by the other.

Key concepts: Glibenclamide, Dissolution, Reproducibility, Dissolution testing, Chromatography, Chemistry, Drug, Significant difference

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