1962•Experimental Biology and MedicineRequires access
Attempts to Enhance Infectivity of Adenovirus Type 8 for Cell Cultures.
L. Hanna, Ernest Jawetz
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Abstract
The prototype strain of adenovirus type 8 grew in Maben cells best at 36°C but yielded maximal infective titers of only 100-300 TCID50/ml. Serial passage at 31 or 39°C did not enhance the infective titer. Serial passage of undiluted degenerated cell culture gave no evidence of an interfering material. The consistently low titer of infective adenovirus type 8 in many different cell lines appears to be a specific characteristic of that agent.