1991•Chemical and Pharmaceutical BulletinOpen access

Synthesis and absolute configuration of optically active 2,3-disubstituted 2,3-dihydro-1,3,4-thia-diazoles.

Kouhei Toyooka, Yoshiyuki Takeuchi, Hiroyuki OHTO, Masayuki Shibuya, Seiju Kubota

Abstract

Optically active 3-substituted 2, 3-dihydro-1, 3, 4-thiadiazoles (2-5) were synthesized by the reaction of aldehyde methylthio(thiocarbonyl)hydrazones (1) and chiral 5-substituted 1, 3-dioxolane-2, 4-diones. The absolute configurations of compounds 2-5 were deduced from their circular dichroism spectra.

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Key concepts: Absolute configuration, Chemistry, Optically active, Aldehyde, Circular dichroism, Thiadiazoles, Dioxolane, Stereochemistry