Studies on Optically Active Amino Acids. XIV. Studies on α-Alkyl-α-amino acids. VII. Determination of Absolute Configuration of Optically Active α-Methylphenylglycine Configuration of Optically Active α-Methylphenylglycine and 1-Methyl-1-phenylpropylamine.

The absolute configuration of (+)-α-methylphenylglycine was proved to be S series by the chemical correlation with R (-)-isovaline. Chemical scheme employed was shown in Chart 1. Moreover, in the course of the chemical correlation, the absolute configuration of (+)-1-methyl-1-phenylpropylamine was also proved to be R series. Preliminary experiments using racemic compounds were also described.