1957•Experimental Biology and MedicineRequires access

Serial Propagation of the Guinea Pig Salivary Gland Virus in Tissue Culture

Janet W. Hartley, Wallace P. Rowe, Robert J. Huebner

Abstract

The guinea pig submaxillary gland virus has been successfully propagated in tissue culture, one strain having been carried through 22 serial passages. The tissue culture passage virus produced characteristic intranuclear inclusion bodies in tissue cultures, demonstrated complement fixing and neutralizing antibody responses in guinea pigs infected with animal passage virus, and produced characteristic disease and histopathology in susceptible guinea pigs. Commercial complement consistently contained high titer CF antibody.

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Key concepts: Guinea pig, Tissue culture, Serial passage, Virus, Biology, Virology, Titer, Salivary gland