2009•Journal of the Mass Spectrometry Society of JapanOpen access

Optimization of a Home-Built Desorption Electrospray Ionization Source and Its Application in Rapid Analysis

Arifumi Yoshimoto, Shoichi Motoki, Yusuke Moriwaki, Hideya Kawasaki, Ryuichi Arakawa

Abstract

High-performance liquid chromatography/mass spectrometry (LC/MS) is the most useful tool for qualitative and quantitative chemical analysis in the life sciences. However, sample preparation and LC separation demand an extraordinary amount of time and effort. Desorption electrospray ionization (DESI) and direct analysis in real time (DART) techniques that obtain mass spectra of samples without difficulty have been developed in recent years. We connected a home-built DESI ion source to an existing mass spectrometer and examined its performance. In this paper, we report the application of DESI to thin-layer chromatography (TLC)/DESI-MS in rapid analysis of medicines in serum and concentrated analysis with a solid-phase extraction disk.

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Key concepts: Desorption electrospray ionization, DART ion source, Mass spectrometry, Extractive electrospray ionization, Chromatography, Direct electron ionization liquid chromatography–mass spectrometry interface, Electrospray ionization, Analytical Chemistry (journal)