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Synergistic effect of glycerol on cytotoxicity of bleomycin in cultured Chinese hamster V79 cells.

Takayoshi Suzuki, Kohfuku Kohda, Yutaka Kawazoe

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Abstract

The cytotoxicity of bloeomycin (BLM) in cultured Chinese hamster V79 cells was greatly potentiated by the simultaneous treatment with 10% glycerol. The treatment with 1 μg/ml BLM for 1 h did not affect the survival fraction, whereas the same treatment in 10% glycerol reduced it to 10-3. No combinations of glycerol with adriamycin, paraguat, hydrogen peroxide, or N-methyl-N-nitrosourea potentiated the cytotoxicities of these chemicals.

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The cytotoxicity of bloeomycin (BLM) in cultured Chinese hamster V79 cells was greatly potentiated by the simultaneous treatment with 10% glycerol. The treatment with 1 μg/ml BLM for 1 h did not affect the survival fraction, whereas the same treatment in 10% glycerol reduced it to 10-3. No combinations of glycerol with adriamycin, paraguat, hydrogen peroxide, or N-methyl-N-nitrosourea potentiated the cytotoxicities of these chemicals.

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Available abstract

The cytotoxicity of bloeomycin (BLM) in cultured Chinese hamster V79 cells was greatly potentiated by the simultaneous treatment with 10% glycerol. The treatment with 1 μg/ml BLM for 1 h did not affect the survival fraction, whereas the same treatment in 10% glycerol reduced it to 10-3. No combinations of glycerol with adriamycin, paraguat, hydrogen peroxide, or N-methyl-N-nitrosourea potentiated the cytotoxicities of these chemicals.

Key concepts: Chinese hamster, Cytotoxicity, Chemistry, Glycerol, Hamster, Bleomycin, Hydrogen peroxide, Cell culture

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Synergistic effect of glycerol on cytotoxicity of bleomycin in cultured Chinese hamster V79 cells. — Research Paper | ScholarLens