1977•Experimental Biology and MedicineRequires access

Effect of Vasoactive Intestinal Polypeptide (VIP) on the Lower Esophageal Sphincter Pressure (LESP)

Satish Rattan, Sami I. Said, Raj K. Goyal

Abstract

The effect of vasoactive intestinal polypeptide (VIP) on the lower esoph-ageal sphincter (LES) was studied in anesthetized opossums. Intravenous administration of VIP caused a dose-related fall in LES pressure. A dose of 8 μg/kg produced a “maximal” fall of 36.8 ± 2.9 mm Hg (80.5 ± 4.5%) in sphincter pressure. The effect of VIP (8 μg/kg) was not antagonized by tetro-dotoxin in the doses which antagonized neural activity in the LES. β-Adrenergic antagonist, propranolol, also failed to antagonize this inhibitory effect of VIP. These studies show that VIP exerts an inhibitory effect on the LES. Moreover, this inhibitory effect may be due to a direct action on the sphincter muscle.

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Key concepts: Vasoactive intestinal peptide, Propranolol, Endocrinology, Inhibitory postsynaptic potential, Antagonist, Internal medicine, Sphincter, Adrenergic antagonist