1987•Cleveland Clinic Journal of MedicineRequires access

Immunological reversal of digitalis toxicity by Fab fragments of digoxin-specific antibodies

Daniel M. Cooper, James D. Maloney, Lynn A. Cooper, J. R. Hodgman, LON W. CASTLE

Abstract

Severe digitalis toxicity is associated with a high mortality. We present a case of advanced digoxin toxicity successfully treated with digoxin-specific antibody Fab fragments, and discuss its mechanism of action. A review of the pharmacokinetics of digitalis as well as the mechanisms of cardiotoxicity and its conventional treatment is presented.

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Key concepts: Medicine, Digoxin, Antibody, Digitalis, Digitalis Toxicity, Toxicity, Pharmacology, Immunology