1995•PubMedRequires access

[The cloning of fragments of homeobox genes expressed during planarian regeneration].

К А Лукьянов, Victor S. Tarabykin, Victor K. Potapov, Evguenia Bekman, S A Luk'ianov

Abstract

The polymerase chain reaction with degenerate primers corresponding to the most conservative amino acids 16-21 (ELEKEF) and 49-54 (WFQNRR) of the Antennapedia class homeodomain was used for the amplification of cDNA from regenerating planarians (asexual race of Dugesia tigrina). A total of six new Antennapedia-like homeobox sequences, designated Dutarh-1-Dutarh-6 (Dugesia tigrina asexual race homeobox gene), were obtained. Their comparison with other homeobox genes using a "Genebee" software (the EMBL Data Library) showed that all sequences except Dutarh-6 belong to the Antennapedia class. Dutarh-6 is closely related to a recently described novel homeobox gene subfamily that includes mouse mesodermal homeobox genes Mox-1 and Mox-2 and rat homeobox gene Gax.

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Key concepts: Homeobox, Homeobox A1, HNF1B, Homeobox protein Nkx-2.5, Biology, Antennapedia, Planarian, Genetics