1982•American Journal of Clinical PathologyRequires access

Determination of Terminal Deoxynucleotidyl Transferase on Bone Marrow Smears by Immunoperoxidase

Sanford A. Stass, Letia Dean, Stephen C. Peiper, Frederick J. Bollum

Abstract

Terminal deoxynucleotidyl transferase (TdT) is a marker of lymphoblastic disorders. Previously, the technique for determining TdT on smears was by indirect immunofluorescence. An immunoperoxidase procedure for detecting TdT on smears is reported. Results are in a comparable range with the indirect immunofluorescent technique. As discussed in this paper, TdT by immunoperoxidase may offer certain advantages over the indirect immunofluorescent procedure.

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Key concepts: Terminal deoxynucleotidyl transferase, Immunoperoxidase, TUNEL assay, Immunofluorescence, Pathology, Bone marrow, Indirect immunofluorescence, Medicine