1991•Chemical and Pharmaceutical BulletinOpen access

Synthesis of Rat Parathymosin .ALPHA. Fragment 1-28 and Examination of Its Inhibitory Activity towards the Restoring Activity of Thymosin .ALPHA.1 on the Impaired T-Lymphocytes of Uremic Patients.

Takashi Abiko, HIROSHI SEKINO

Abstract

A fragment corresponding to N-terminal octaeicosapeptide of rat parathymosin alpha was synthesized by assembling 5 peptide fragments, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio 1:1) in trifluoroacetic acid in the presence of dimethylselenium. Incubation of impaired T-lymphocytes isolated from uremic patients with the synthetic parathymosin alpha fragment 1-28 showed no immunological restoring effect, but when it was administered together with thymosin alpha 1, it appeared to suppress the restoring effect of the thymosin alpha 1 on the impaired T-lymphocytes of uremic patients.

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Key concepts: Thymosin, Chemistry, Trifluoroacetic acid, Inhibitory postsynaptic potential, Alpha (finance), Peptide fragment, Peptide, Incubation