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2012•Chinese Science Bulletin (Chinese Version)Requires access

Principle and applications of extractive electrospray ionization mass spectrometry

Xinglei Zhang, Bin Jia, Jianhua Ding, Huanwen Chen, Shuiping Yang

Open publisher page 4 citations

Abstract

Extractive electrospray ionization mass spectrometry (EESI-MS), an ambient ionization technique for direct analysis of complex samples without sample pretreatment, is undergoing rapid development, and has been wildly used in the analysis of liquids, aerosols, solid surfaces and viscous liquids. In this paper, the mechanism of EESI is introduced, the specific implementations and characteristics of EESI-MS in the analysis of real samples are described, and the new applications of EESI-MS are discussed. Moreover, the usability of EESI-MS in the field of food and drug safety; public security; chemical reaction mechanisms; metabolomics; protein analysis; clinical diagnostic and environmental monitoring are exemplified using cases demonstrated in the literature.

About this research paper

What this paper is about

Extractive electrospray ionization mass spectrometry (EESI-MS), an ambient ionization technique for direct analysis of complex samples without sample pretreatment, is undergoing rapid development, and has been wildly used in the analysis of liquids, aerosols, solid surfaces and viscous liquids. In this paper, the mechanism of EESI is introduced, the specific implementations and characteristics of EESI-MS in the analysis of real samples are described, and the new applications of EESI-MS are discussed. Moreover, the usability of EESI-MS in the field of food and drug safety; public security; chemical reaction mechanisms; metabolomics; protein analysis; clinical diagnostic and environmental monitoring are exemplified using cases demonstrated in the literature.

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OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Extractive electrospray ionization mass spectrometry (EESI-MS), an ambient ionization technique for direct analysis of complex samples without sample pretreatment, is undergoing rapid development, and has been wildly used in the analysis of liquids, aerosols, solid surfaces and viscous liquids. In this paper, the mechanism of EESI is introduced, the specific implementations and characteristics of EESI-MS in the analysis of real samples are described, and the new applications of EESI-MS are discussed. Moreover, the usability of EESI-MS in the field of food and drug safety; public security; chemical reaction mechanisms; metabolomics; protein analysis; clinical diagnostic and environmental monitoring are exemplified using cases demonstrated in the literature.

Key concepts: Extractive electrospray ionization, Direct electron ionization liquid chromatography–mass spectrometry interface, Mass spectrometry, Electrospray ionization, Chemistry, Chromatography, Desorption electrospray ionization, Ionization

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