Effect of Chlormadinone Acetate Treatment on Canine Prostatic Hyperplasia

Dogs with prostatic hyperplasia were treated with either oral administration or subcutaneous implantation of chlormadinone acetate (CMA). In 4 orally treated (1-2mg/kg/day for 9 to 35 days) cases blood CMA levels increased to 94 to 280ng/ml immediately after starting the treatment, decreasing shortly after stopping administration. In 5 cases given CMA implantation (10mg) blood levels were maintained below 10ng/ml for a year or longer. In all treated cases the prostate decreased in size and most clinical signs disappeared. The blood cortisol and progesterone levels decreased immediately after starting the treatment, while no remarkable changes were observed on testosterone and estradiol levels.