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1976•ReproductionOpen access

Effects of low doses of chlormadinone acetate in the rat

Manorma Sharma, Geeta Lal, Dayan Jacob

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Abstract

Chlormadinone acetate (6-chloro-6,17α·acetoxyprogesterone) is a synthetic highly potent progestagen with antiandrogenic properties (Kincl, Maqueo & Dorfman, 1965). Treatment with chlormadinone acetate causes inhibition of spermatogenesis in the rabbit (Ericsson, Dutt & Archdeacon, 1964), and in the rat in which the effect was reversible (Dörner, Gotz & Mainz, 1972). Dörner et al. (1972) used a dose of 10 mg chlormadinone acetate/day, but in the present study lower doses were investigated.

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What this paper is about

Chlormadinone acetate (6-chloro-6,17α·acetoxyprogesterone) is a synthetic highly potent progestagen with antiandrogenic properties (Kincl, Maqueo & Dorfman, 1965). Treatment with chlormadinone acetate causes inhibition of spermatogenesis in the rabbit (Ericsson, Dutt & Archdeacon, 1964), and in the rat in which the effect was reversible (Dörner, Gotz & Mainz, 1972). Dörner et al. (1972) used a dose of 10 mg chlormadinone acetate/day, but in the present study lower doses were investigated.

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Available abstract

Chlormadinone acetate (6-chloro-6,17α·acetoxyprogesterone) is a synthetic highly potent progestagen with antiandrogenic properties (Kincl, Maqueo & Dorfman, 1965). Treatment with chlormadinone acetate causes inhibition of spermatogenesis in the rabbit (Ericsson, Dutt & Archdeacon, 1964), and in the rat in which the effect was reversible (Dörner, Gotz & Mainz, 1972). Dörner et al. (1972) used a dose of 10 mg chlormadinone acetate/day, but in the present study lower doses were investigated.

Key concepts: Chlormadinone acetate, Chemistry, Population, Medicine, Endocrinology, Internal medicine, Andrology, Pharmacology

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