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Concanavalin A-Induced Sensitization of Mice to Histamine

Lois S. Cronholm, Ron J. Doyle, Charles W. Fishel

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Abstract

The jack bean phytohemagglutinin, concanavalin A, induced histamine lethality in CFW mice. Sensitization depended upon the dose of concanavalin A, with an LD50 of 0.5 mg. The sensitization was time dependent, reaching a maximum at 4 days and declining at 6 days. An inhibitor of concanavalin A-polysaccharide precipitin interactions, D-glucose, had no effect on the sensitization. Concanavalin A did not alter the sensitization of mice by B. pertussis.

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What this paper is about

The jack bean phytohemagglutinin, concanavalin A, induced histamine lethality in CFW mice. Sensitization depended upon the dose of concanavalin A, with an LD50 of 0.5 mg. The sensitization was time dependent, reaching a maximum at 4 days and declining at 6 days. An inhibitor of concanavalin A-polysaccharide precipitin interactions, D-glucose, had no effect on the sensitization. Concanavalin A did not alter the sensitization of mice by B. pertussis.

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The jack bean phytohemagglutinin, concanavalin A, induced histamine lethality in CFW mice. Sensitization depended upon the dose of concanavalin A, with an LD50 of 0.5 mg. The sensitization was time dependent, reaching a maximum at 4 days and declining at 6 days. An inhibitor of concanavalin A-polysaccharide precipitin interactions, D-glucose, had no effect on the sensitization. Concanavalin A did not alter the sensitization of mice by B. pertussis.

Key concepts: Concanavalin A, Sensitization, Histamine, Precipitin, Chemistry, Pharmacology, Immunology, Endocrinology

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