2015International Journal of Students ResearchRequires access

Central giant cell granuloma: A case report with diagnostic dilemma

Garima Singh, Ashish Thakur, Heena Sadiq, Priti Gupta

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Abstract

Central Giant Cell Granuloma (CGCG) was differentiated from Giant Cell Tumor of bone by Jaffe in 1953. Various authors have advocated this intraosseous lesion as a reactive lesion or developmental anomaly or a benign neoplasm. Actual etiology is not comprehensible till date and it has also been hypothesized to have a genetic etiology. Lesions are most commonly found in mandible but frequently crossing the midline. However, variable clinical features and radiological changes have been demonstrated by giant cell lesions of the jaws. In this case report, a young female patient reported with the chief complaint of swelling in right mandibular posterior tooth region since 2 wks after dental extraction from the same region. The patient underwent the treatment as surgical curettage followed by removal of the lesion and subsequent histopathological examination which confirmed the diagnosis of CGCG. There was no recurrence reported in 10 months of follow up.

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What this paper is about

Central Giant Cell Granuloma (CGCG) was differentiated from Giant Cell Tumor of bone by Jaffe in 1953. Various authors have advocated this intraosseous lesion as a reactive lesion or developmental anomaly or a benign neoplasm. Actual etiology is not comprehensible till date and it has also been hypothesized to have a genetic etiology. Lesions are most commonly found in mandible but frequently crossing the midline. However, variable clinical features and radiological changes have been demonstrated by giant cell lesions of the jaws. In this case report, a young female patient reported with the chief complaint of swelling in right mandibular posterior tooth region since 2 wks after dental extraction from the same region. The patient underwent the treatment as surgical curettage followed by removal of the lesion and subsequent histopathological examination which confirmed the diagnosis of CGCG. There was no recurrence reported in 10 months of follow up.

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Available abstract

Central Giant Cell Granuloma (CGCG) was differentiated from Giant Cell Tumor of bone by Jaffe in 1953. Various authors have advocated this intraosseous lesion as a reactive lesion or developmental anomaly or a benign neoplasm. Actual etiology is not comprehensible till date and it has also been hypothesized to have a genetic etiology. Lesions are most commonly found in mandible but frequently crossing the midline. However, variable clinical features and radiological changes have been demonstrated by giant cell lesions of the jaws. In this case report, a young female patient reported with the chief complaint of swelling in right mandibular posterior tooth region since 2 wks after dental extraction from the same region. The patient underwent the treatment as surgical curettage followed by removal of the lesion and subsequent histopathological examination which confirmed the diagnosis of CGCG. There was no recurrence reported in 10 months of follow up.

Key concepts: Central giant-cell granuloma, Curettage, Etiology, Medicine, Lesion, Giant cell, Mandible (arthropod mouthpart), Histopathological examination

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