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Alterations of Pancreas During Cortisone Diabetes in Rabbits.

Sydney S. Lazarus, Sergio A. Bencosme

Open publisher page 38 citations

Abstract

1. Cortisone acetate administered intramuscularly to rabbits caused the gradual appearance of glycosuria which reached a maximum at the 5th to 9th days and then declined. Increased dosage reestablished the glycosuria but it again regressed. Morphologically, the most prominent lesion observed was ductular and centroacinar proliferation and the formation of irregularly shaped and “Mulberry” islets. In addition, numerous mitotic beta cells were observed up to 10 days after starting cortisone treatment.

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What this paper is about

1. Cortisone acetate administered intramuscularly to rabbits caused the gradual appearance of glycosuria which reached a maximum at the 5th to 9th days and then declined. Increased dosage reestablished the glycosuria but it again regressed. Morphologically, the most prominent lesion observed was ductular and centroacinar proliferation and the formation of irregularly shaped and “Mulberry” islets. In addition, numerous mitotic beta cells were observed up to 10 days after starting cortisone treatment.

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Available abstract

1. Cortisone acetate administered intramuscularly to rabbits caused the gradual appearance of glycosuria which reached a maximum at the 5th to 9th days and then declined. Increased dosage reestablished the glycosuria but it again regressed. Morphologically, the most prominent lesion observed was ductular and centroacinar proliferation and the formation of irregularly shaped and “Mulberry” islets. In addition, numerous mitotic beta cells were observed up to 10 days after starting cortisone treatment.

Key concepts: Cortisone, Glycosuria, Endocrinology, Internal medicine, Pancreas, Diabetes mellitus, Cortisone acetate, Lesion

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